Nitric Oxide and COVID

A recent review published by researchers at Uppsala University suggests that nitric oxide (N.O.) has promise as a therapeutic to control the replication and rapid spread of the SARS-CoV-2 virus.Nitric Oxide and COVID

What is Nitric Oxide?

Nitric oxide (N.O.) is an antimicrobial and anti-inflammatory molecule with key roles in pulmonary vascular function in the context of viral infections and other pulmonary diseases. Nitric Oxide is an important biological signaling molecule that supports normal endothelial function and protects your mitochondria. It is stored in the lining of your blood vessels aiding in vasodilation (or helping relax and widen the diameter of your blood vessels) and healthy blood flow. This allows for efficient oxygenation of tissues and organs, and aids in the removal of waste and carbon dioxide. More importantly, N.O. infuses into areas that are hypoxic (in need of oxygen) such as the heart and the brain.

NItric Oxide Effectively Inhibits SARS-CoV-2 Replication

According to Redox Biology, “N.O. has an antiviral effect against SARS-CoV-2…Inhaled N.O. improved arterial oxygenation in hypoxemic patients by redistributing blood flow in the lungs to better ventilated regions, and counteracted blood clotting, both effects being of importance of COVID-19 patients.”

N.O. is also known to have broad spectrum antimicrobial effects. Swedish researchers have demonstrated that N.O. effectively inhibits the replication of SARS-CoV-2 in vitro by targeting the main protease. This is a key enzyme in the virus’ life cycle, which makes it an attractive target for drug development.

How to Increase Nitric Oxide Production Naturally

Vegetables such as: celery, lettuce, beetroot, spinach, and arugula are high in nitrates, which are then converted into Nitric Oxide. Several analyses have shown that eating nitrate rich vegetables can greatly affect Nitric Oxide levels.

However, Nitric Oxide degrades quickly in the bloodstream - meaning that it must be constantly replenished. One way to increase its stability and limit its breakdown is by consuming (or supplementing with) antioxidants. These molecules neutralize free radicals and help to extend the lifespan of Nitric Oxide. Antioxidants are found in food primarily of plant origin (such as fruits, vegetables, nuts, seeds, and grains). Antioxidants can also be infused via glutathione IV/IM therapy. Glutathione is known as the master antioxidant of the body – aiding in total body detoxification and N.O. life extension.


Exercise gets the body’s blood pumping and thus helps to improve endothelial function. In doing so, the endothelium (lining of the blood vessels) is maintained and blood vessels remain healthy and able to properly shuttle blood and produce adequate amounts of Nitric Oxide.

Although eating right and exercising regularly are both important, sometimes they are not enough to maintain optimal Nitric Oxide levels. Nitric Oxide can actually be taken in the form of a tablet, making it a convenient and effective way to quickly increase your body’s N.O. levels. At The Hormone Zone, we offer a professional Nitric Oxide supplement, Neo40, that can be purchased on our online store or in-office. 


DISCLAIMER: To date, there are no known FDA approved treatments for COVID-19 (aka SARS-CoV, aka coronavirus). This website and all digital communications are intended to provide educational information only. Please consult with a medical professional if you have any symptoms related to COVID-19 or believe you have been exposed to the virus.