The Role of Progesterone in Men vs. Women

The role of progesterone has been studied extensively in females due to its role in fetal gestation and menstruation. This blog post will explore its role in females briefly and compare that to its effect in men.

In women, progesterone prepares the lining of the uterus for egg implantation, helps the fetus to develop, stimulates breast tissue promoting lactation and strengthens the pelvic muscles for labor. It plays a role in menstruation by bringing about ovulation and maintains the thickness of the uterine lining to allow for implantation of a fertilized egg.


In men, progesterone is produced by both the adrenal gland and the testicles. It influences the production and activation of sperm, testosterone biosynthesis in the leydig cells of the testes, improves sleep and inhibits the enzyme 5-alpha reductase thus reducing DHT levels. Low levels of progesterone in males can produce low libido, hair loss, weight gain, fatigue, bone and muscle loss and ED. Progesterone levels decrease along with testosterone levels as men age despite estrogen levels rising during that time. The levels of progesterone in men are similar to the levels found in women during the follicular phase of menstruation (0.2-1.2 ng/ml).

To better understand your hormone levels and how they affect your overall health, make an appointment with The Hormone Zone today.


1. The Journal of Clinical Endocrinology & Metabolism, Jan 1 1974, 38(1):142-147, “Inhibition of Testosterone Conversion to Dihydrotestosterone in Men Treated Percutaneously by Progesterone”

2. The Aging Male, 2004, Vol. 7(3):236-257, “Progesterone: the forgotten hormone in men?”

3. Fertility and Sterility, 1992, 58(6):1191-1198, “Direct effects of progesterone and antiprogesterone on human sperm hyperactivated motility and acrosome reaction”