Thymosin-B4 and Hair Growth

thymosin (2)

Thymosin Beta-4 is a 43 amino acid peptide that has potent anti-inflammatory properties and promotes healing all throughout the body. Naturally, it is found in higher concentrations at injury sites due to its innate ability to repair tissue damage and regulate cell migration to a cite. It is known to improve wound healing in the brain, spinal cord, heart, and also the skin. Its claim to fame, however, is its ability to promote hair growth. 

There have been multiple studies showing its effects on stimulating hair growth. Mouse studies have shown that a specific subset of hair follicular keratinocytes in mouse skin expresses Thymosin beta-4 in a highly coordinated manner during the hair growth cycle. These keratinocytes originate in the hair follicle bulge region, a niche for skin stem cells. 

Thus, it was shown that Thymosin beta-4 accelerates hair growth, in part, due to its effect on critical events in the active phase of the hair follicle cycle, including promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and extracellular matrix remodeling.

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