Vitamin C and COVID

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Your immune system is your frontline defense against all illness, including respiratory viruses such as Sars-Cov-2. At the Hormone Zone, we whole-heartedly believe in prevention and providing you with information to keep your immune system 

optimal during this season. Mechanistic and clinical data show that maintaining adequate nutrient amounts of vitamins A, B12, B6, C, D, E, B9, Zinc, Selenium, N-acetylcysteine (NAC), copper, and magnesium are of utmost importance. Let’s take a deeper look at our powerhouse Vitamin C

Vitamin C taken daily and at higher therapeutic doses has shown potent antiviral activity, specifically with viral inactivation. The research has pointed out a correlation with Vitamin C deficiency and increased severity of disease specifically with COVID-19. An article coauthored by Dr. Paul Mari (who is currently heading up the Frontline COVID19 Critical Care Alliance) on December 7, 2020 presented a review for vitamin C based treatment for respiratory illness, sepsis, and COVID19. Vitamin C has immune boosting properties including immune modulation,  antiviral, anti-inflammatory, anti-thrombotic, and anti-oxidant effects. Repairing tissues, increased immune function, and enhanced blood vessel and lung barrier integrity make vitamin C an integral adjunctive therapy in prevention and treatment of COVID19. 

Even more specific to COVID19, vitamin C acts on ACE2 receptors; which is the known viral entry point for Sars-Cov-2. Vitamin C eliminates the up-regulation of ACE2 receptors induced by IL-7, therefore decreasing the likelihood of Sars-Cov-2 to enter the cell. Further, vitamin C increases the presence of specific interferons that act as our primary antiviral defense mechanism- a pathway that Sars-Cov-2 slows down. This further points out the importance of adequate intake of vitamin C daily for prevention and therapy.

But why must we supplement Vitamin C? Our bodies do not make vitamin C- we must ingest this from our nutrition, which getting in adequate amounts from diet alone is not overly feasible. Yes, foods such as bell peppers, blueberries, strawberries, blackberries, kiwi and oranges have high levels of Vitamin C, but it is unlikely you will get what is needed through diet alone.


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Recommended doses of vitamin C daily are at least 200-400mg if you are well. If you are fighting an illness, then amounts as high as 2-8g/day orally are shown to decrease the incidence and duration of respiratory infections. 

In the event of severe infections, such as COVID19, Vitamin C IV therapy should be considered as adjunctive care. The research shows dosing via IV 6-8g daily to reduce mortality, severity of illness, and reduced chance of prolonged hospital stay and mechanical ventilation in patients with severe respiratory infection. Click here to learn more about the IV Therapy we offer at The Hormone Zone. 

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1. Nutrients April 23, 2020; 12(4): 1181

2. Nutrients December 7, 2020; 12(12): 3760

3. Frontline COVID-19 Critical Care Alliance

4. FLCCC Alliance I-MASK+ Protocol

5. FLCCC MATH+ Hospital Protocol

6. Journal of Intensive Care Medicine December 15, 2020 DOI: 10.1177/0885066620973585

7. Alliance for Natural Health December 16, 2020


9. Nutrients December 7, 2020; 12(12): 3760, 2. Vitamin C Deficiency in Pneumonia, Sepsis and COVID-19

10. Nutrients December 7, 2020; 12(12): 3760, 3. Mechanisms of Action of Vitamin C in Infections, Sepsis and COVID-19

11. Nutrients December 7, 2020; 12(12): 3760, 7. Clinical Evidence for the Role of Vitamin C in COVID-19

12. Research Square August 10, 2020 DOI: 10.21203/ (version 1)

13. Research Square September 23, 2020 DOI: 10.21203/ (version 2)

14. Nutrients December 7, 2020; 12(12): 3760, 1. Introduction

DISCLAIMER: To date, there are no known FDA approved treatments for COVID-19 (aka SARS-CoV, aka coronavirus). This website and all digital communications are intended to provide educational information only. Please consult with a medical professional if you have any symptoms related to COVID-19 or believe you have been exposed to the virus.